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系統介紹

FreezeScan(CleverSys, Inc., CSI)是Gene&I聯合CleverSys推出的進行條件性恐懼實驗的分析系統。可以分析在一個固定的活動箱內任意角度的視頻文件，它可以精確分析嚙齒類動物恐懼行為的發生和結束。

FreezeScan(CleverSys, Inc., CSI)不僅可以精確地監測動物恐懼行為，還可以在實驗過程中以數字和圖形的形式提供精確地動物瞬時活動度水平，使震驚反應研究成為可能。

除此之外，通過額外的實驗硬件，還可以進行動物共情行為的研究。

系統特點

●  全功能條件性恐懼行為分析系統

●  主控機可同時控制64個裝置

●  活動度測量可進行震驚反應研究

●  高通量模式可同時進行4個活動箱內的實驗

●  實時分析功能和錄像后分析功能

●  自動監測視頻中視覺信號的開關（如LED燈）

●  可進行多種時間間隔設置

●  自動生成時間間隔數據

●  簡易雙擊回放功能

Reference

I-Ting Judy Wang, Megan Allen, Darren Goffin, Xinjian Zhu, Andrew H. Fairless, Edward S. Brodkin, Steve J. Siegel, Eric D. Marsh, Julie A. (2012) Blendy, and ZhaolanZhou ,(2012) Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice, PNAS, Dec 2012; 109: 21516 – 21521.

Lin H-C, Gean P-W, Wang C-C, Chan Y-H, Chen PS (2013) The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model. PLoS ONE 8(1): e55248. doi:10.1371/journal.pone.0055248.

Sotres-Bayon, Francisco; Sierra-Mercado, Demetrio; Pardilla-Delgado, Enmanuelle; Quirk, Gregory??J. (2012) Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs, Neuron doi:10.1016/j.neuron.2012.09.028 (volume 76 issue 4 pp.804 - 812).

Kristen A. Rahn, Crystal C. Watkins, Jesse Alt, Rana Rais, MarigoStathis, Inna Grishkan, Ciprian M. Crainiceau, Martin G. Pomper, Camilo Rojas, Mikhail V. Pletnikov, Peter A. Calabresi, Jason Brandt, Peter B. Barker, Barbara S. Slusher, and Adam I. Kaplin, (2012) Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis, PNAS 2012; doi:10.1073/pnas.1209934109.

Pushpinder K. Multani, Rachel Hodge, Marcel A. Estévez, Ted Abel, Hank Kung, Mark Alter, Bethany Brookshire, Irwin Lucki, Aleksandra H. Nall, Konrad Talbot, Glenn A. Doyle, Falk W. Lohoff, (2012) VMAT1 Deletion Causes Neuronal Loss in the Hippocampus and Neurocognitive Deficits in Spatial Discrimination, Neuroscience Available online 28 November 2012.