巴恩斯迷宮（Barnes Maze）是美國學者Carol ABarnes 利用嚙齒類動物避光喜暗且愛探究的特性而發(fā)明的用于檢測動物空間記憶的模型。實驗時將動物置于高臺的中央，通過觀察并記錄實驗動物找到正確洞口的時間，以及進入錯誤洞口的次數(shù)來反應動物的空間記憶能力。也可通過記錄動物重復進入錯誤的洞口數(shù)來測量動物的工作記憶。
相關產(chǎn)品
Reference
Kallop D Y, Meilandt W J, Gogineni A, et al. A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer’s Disease-Related Pathophysiology in Murine Models[J]. The Journal of Neuroscience, 2014, 34(19): 6425– 6437.
Hanson J E, Meilandt W J, Gogineni A, et al. Chronic GluN2B Antagonism Disrupts Behavior in WildType Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer’s Disease Mouse Models[J]. The Journal of Neuroscience, 2014, 34(24): 8277– 8288.
Kallop D Y, Meilandt W J, Goginen A, et al. Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models[J]. The Journal of Neuroscience, 2014, 34(19): 6425-6437.
Gheyara A L, Ponnusamy R, Djukic B, et al. Tau Reduction Prevents Disease in a Mouse Model of Dravet Syndrome[J]. Annals of Neurology, 2014.
Hanson J E, Weber M, Meilandt W J, et al. GluN2B Antagonism Affects Interneurons and Leads to Immediate and Persistent Changes in Synaptic Plasticity, Oscillations, and Behavior[J]. Neuropsychopharmacology, 2013, 38: 1221-123